Human ADRA2C/Galpha15 Stable Cell Line-Chem-1



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The endogenous catecholamines epinephrine and norepinephrine have profound effects on smooth muscle activity, cardiac function, carbohydrate and fat metabolism, hormone secretion, neurotransmitter release, and central nervous system actions. These activities are mediated by GPCRs belonging to two subfamilies, the alpha- and beta-adrenoceptors. The alpha2 adrenergic receptor subfamily members, consisting of alpha2A, alpha2B, and alpha2C, couple primarily to Gi to inhibit cAMP production, and play an important role in regulation of cardiovascular and CNS function. Experiments with alpha2C-selective agonists and knock-out mice lacking alpha2C demonstrate that activation of alpha2C results in impaired motor behavior and altered memory.

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Human HRH3/Gi/Go Stable Cell Line-CHO

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Human OPRD1/Gi Stable Cell Line-CHO

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The melanocortin 1 receptor is one of the key proteins in regulating hair and skin color. A member of the family of G-protein-coupled receptors, it functions at the surface of pigment producing cells (called melanocyt Human MC1R/Gs Stable Cell Line-1321N1

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Human OPRL1/Gi Stable Cell Line-CHO

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Human GRM4/Gi Stable Cell Line-CHO

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of nor Human PTH1R/Gs Stable Cell Line-CHO

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The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this Human FSHR/Gs Stable Cell Line-CHO

Human FSHR/Gs Stable Cell Line-CHO

Follicle stimulating hormone receptor belongs to a family of G-protein coupled receptors which activate adenylate cyclase.FSHR is a transmembrane receptor that interacts with the follicle stimulating hormone(FSH). In Human ADRB2/Gs Stable Cell Line-CHO

Human ADRB2/Gs Stable Cell Line-CHO

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Human DRD4/Gi Stable Cell Line-CHO

Human DRD4/Gi Stable Cell Line-CHO

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Human ADRA2A/Gi Stable Cell Line-CHO

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Human RXFP1/Gs/Gi/Go Stable Cell Line-CHO

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Rat Drd1/Gs Stable Cell Line-CHO

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Human SSTR3/Gi Stable Cell Line-CHO

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Human SSTR5/Gi/Go Stable Cell Line-CHO

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Human FFAR3/Gi Stable Cell Line-CHO

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Human HTR1A/Gi Stable Cell Line-CHO

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Human RXFP4/Gi/Go Stable Cell Line-CHO

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Human LPAR1/Gi Stable Cell Line-CHO

Lysophosphatidic acid (LPA) is a small, bioactive phospholipid that mediates multiple cellular responses, including proliferation, differentiation, motility, and survival in both normal physiology and disease. The ext Human GRM3/Gi Stable Cell Line-CHO

Human GRM3/Gi Stable Cell Line-CHO

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Human CXCR6/Gi Stable Cell Line-CHO

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Human FPR1/Gi Stable Cell Line-CHO

The gene FPR1 encodes the formylpeptide receptor (FPR), which is a G-protein-coupled receptor that mediates chemotaxis of phagocytic leukocytes induced by bacterial peptide N-formyl-methionyl-leucyl-phenylalanine (fML Human RXFP2/Gs Stable Cell Line-CHO

Human RXFP2/Gs Stable Cell Line-CHO

This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isof Human HCAR3/Gi Stable Cell Line-CHO

Human HCAR3/Gi Stable Cell Line-CHO

Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Human S1PR1/Gi Stable Cell Line-CHO

Human S1PR1/Gi Stable Cell Line-CHO

Edg receptors constitute of family of 8 GPCRs (designated as Edg-1 through Edg-8) that can be further sub-classified as sphingosine 1-phosphate receptors (S-1-P) and lysophosphatidic acid (LPA) receptors. The Edg-1 re Human HTR1F/Gi Stable Cell Line-CHO

Human HTR1F/Gi Stable Cell Line-CHO

Relevance 5HT1F is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediat Human NPFFR2/Gi Stable Cell Line-CHO

Human NPFFR2/Gi Stable Cell Line-CHO

This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regu Human GIPR/Gs Stable Cell Line-CHO

Human GIPR/Gs Stable Cell Line-CHO

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Human APLNR/Gi Stable Cell Line-CHO

This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and pla Human GRM2/Gi Stable Cell Line-CHO

Human GRM2/Gi Stable Cell Line-CHO

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G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. Human AVPR2/Gs Stable Cell Line-CHO

Human AVPR2/Gs Stable Cell Line-CHO

V2, a G protein coupled receptor, also called arginine vasopressin receptor 2 (AVPR2), is a receptor for neurohypophyseal peptide [Arg8]-vasopressin. It is expressed in the kidney tubule, mainly in the membrane of cel Human HTR7/Gs Stable Cell Line-CHO

Human HTR7/Gs Stable Cell Line-CHO

The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin. The 5-HT7 receptor is expressed in a variety of tissues, particularly in the brain, Human GPR35/Gi/Go Stable Cell Line-CHO

Human GPR35/Gi/Go Stable Cell Line-CHO

G protein-coupled receptors (GPRs, or GPCRs) contain 7 hydrophobic transmembrane domains embedded in hydrophilic intra- and extracellular loops and transduce a variety of hormone, endogenous peptide, and neurotransmit Human TSHR/Gs/Gq Stable Cell Line-CHO

Human TSHR/Gs/Gq Stable Cell Line-CHO

The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate Human C3AR1/Gi/Go Stable Cell Line-CHO

Human C3AR1/Gi/Go Stable Cell Line-CHO

C3a receptor (C3a anaphylatoxin chemotactic receptor) is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. The receptor is widely expressed in many hematopoietic cell lines, throughout the CNS Human HTR7/Gs Stable Cell Line-U2OS

Human HTR7/Gs Stable Cell Line-U2OS

The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin. The 5-HT7 receptor is expressed in a variety of tissues, particularly in the brain, Human NPY1R/Gi/Go Stable Cell Line-CHO

Human NPY1R/Gi/Go Stable Cell Line-CHO

NPY1R (Neuropeptide Y receptor type 1) is a receptor for neuropeptide Y that is the most abundant peptide present in the mammalian central and peripheral nervous system. Neuropeptide Y exhibits a variety of potent cen Human GPR84/Gi/Go Stable Cell Line-CHO

Human GPR84/Gi/Go Stable Cell Line-CHO

Human GPR84 is a G protein-coupled receptor with 396 amino acids. The hgpr84 transcript was found in brain, heart, muscle, colon, thymus, spleen, kidney, liver, intestine, placenta, lung and leukocytes. A study in GPR Human PTGER3/Gi/Go Stable Cell Line-CHO

Human PTGER3/Gi/Go Stable Cell Line-CHO

Prostaglandin E2 (PGE2) is involved in a number of physiologic and pathophysiologic events in many tissues of the body. The biologic effects of PGE2 are mediated through interaction with specific membrane-bound G prot Human HTR5A/Gi/Go Stable Cell Line-CHO

Human HTR5A/Gi/Go Stable Cell Line-CHO

The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a m Human CALCR/Gs Stable Cell Line-1321N1

Human CALCR/Gs Stable Cell Line-1321N1

Calcitonin receptor (CT or CALCR) is a receptor for calcitonin. In the presence of the receptor activity modifying proteins (RAMP1, 2 or 3), it acts as a receptor for amylin. CT is expressed in brain, bone, stomach, i Human HTR1B/Gi Stable Cell Line-CHO

Human HTR1B/Gi Stable Cell Line-CHO

The human serotonin receptor 5-HT1B is a G protein-coupled receptor. 5-HT1B receptors are present in many parts of the central nervous system, but most notably, can be found in the basal ganglia, striatum, and frontal Human CALCRL+RAMP1/Gs Stable Cell Line-1321N1

Human CALCRL+RAMP1/Gs Stable Cell Line-1321N1

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with a Human CALCRL+RAMP2/Gs Stable Cell Line-1321N1

Human CALCRL+RAMP2/Gs Stable Cell Line-1321N1

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with a Human ADRB3/Gs Stable Cell Line-U2OS

Human ADRB3/Gs Stable Cell Line-U2OS

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Human CALCR+RAMP1/Gs Stable Cell Line-1321N1

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with a Mouse Gipr/Gs Stable Cell Line-CHO

Mouse Gipr/Gs Stable Cell Line-CHO

The gastric inhibitory polypeptide receptor (GIP-R) also known as the glucose-dependent insulinotropic polypeptide receptor is a protein that in humans is encoded by the GIPR gene. The GIP-R is seven-transmembrane pro Human CHRM1/Galpha15 Stable Cell Line-Chem-1

Human CHRM1/Galpha15 Stable Cell Line-Chem-1

The muscarinic acetylcholine receptor family consists of five GPCRs that mediate some of the neurotransmission functions of acetylcholine in the CNS and the periphery. The M1 receptor, along with the M3 and M5 recepto Human CHRM3/Galpha15 Stable Cell Line-Chem-1

Human CHRM3/Galpha15 Stable Cell Line-Chem-1

The muscarinic acetylcholine receptor (mAChR) family consists of five GPCRs that mediate some of the neurotransmission functions of acetylcholine in the CNS and the periphery. The M1, M3 and M5 receptors couple to Gq Human CHRM4/Galpha15 Stable Cell Line-Chem-4

Human CHRM4/Galpha15 Stable Cell Line-Chem-4

The muscarinic acetylcholine receptor (mAChR) family consists of five GPCRs that mediate some of the neurotransmission functions of acetylcholine in the CNS and the periphery. The M1, M3 and M5 receptors couple to Gq Human CHRM2/Galpha15 Stable Cell Line-Chem-1

Human CHRM2/Galpha15 Stable Cell Line-Chem-1

The muscarinic acetylcholine receptor (mAChR) family consists of five GPCRs that mediate some of the neurotransmission functions of acetylcholine in the CNS and the periphery. The M1, M3 and M5 receptors couple to Gq Human ADORA1/Galpha15 Stable Cell Line-Chem-3

Human ADORA1/Galpha15 Stable Cell Line-Chem-3

Extracellular adenosine mediates a multitude of biological effects, including wakefulness, antiarrythmia, bronchoconstriction and response to ischemia and oxidative stress. A family of four GPCR adenosine receptors, A Human ADORA2A/Clytin Stable Cell Line-HEK293

Human ADORA2A/Clytin Stable Cell Line-HEK293

Extracellular adenosine mediates a multitude of biological effects, including wakefulness, antiarrythmia, bronchoconstriction and response to ischemia and oxidative stress. A family of four G protein-coupled adenosine Human ADORA2B/Galpha15 Stable Cell Line-Chem-3

Human ADORA2B/Galpha15 Stable Cell Line-Chem-3

Extracellular adenosine mediates a multitude of biological effects, including wakefulness, antiarrythmia, bronchoconstriction and response to ischemia and oxidative stress. A family of four G protein-coupled adenosine Human ADORA3/Galpha15 Stable Cell Line-Chem-3

Human ADORA3/Galpha15 Stable Cell Line-Chem-3

Extracellular adenosine mediates a multitude of biological effects, including wakefulness, antiarrythmia, bronchoconstriction and response to ischemia and oxidative stress. A family of four GPCR adenosine receptors, A Human ADRA1A/Galpha15 Stable Cell Line-Chem-1

Human ADRA1A/Galpha15 Stable Cell Line-Chem-1

The endogenous catecholamines epinephrine and norepinephrine have profound effects on smooth muscle activity, cardiac function, carbohydrate and fat metabolism, hormone secretion, neurotransmitter release, and central Human ADRA1B/Galpha15 Stable Cell Line-Chem-1

Human ADRA1B/Galpha15 Stable Cell Line-Chem-1

The endogenous catecholamines epinephrine and norepinephrine have profound effects on smooth muscle activity, cardiac function, carbohydrate and fat metabolism, hormone secretion, neurotransmitter release, and central Human ADRA1D/Galpha15 Stable Cell Line-Chem-1

Human ADRA1D/Galpha15 Stable Cell Line-Chem-1

The endogenous catecholamines epinephrine and norepinephrine have profound effects on smooth muscle activity, cardiac function, carbohydrate and fat metabolism, hormone secretion, neurotransmitter release, and central Human ADRA2A/Galpha15 Stable Cell Line-Chem-1

Human ADRA2A/Galpha15 Stable Cell Line-Chem-1

The endogenous catecholamines epinephrine and norepinephrine have profound effects on smooth muscle activity, cardiac function, carbohydrate and fat metabolism, hormone secretion, neurotransmitter release, and central Human ADRA2C/Galpha15 Stable Cell Line-Chem-1

Human ADRA2C/Galpha15 Stable Cell Line-Chem-1

The endogenous catecholamines epinephrine and norepinephrine have profound effects on smooth muscle activity, cardiac function, carbohydrate and fat metabolism, hormone secretion, neurotransmitter release, and central Human ADRB1/Galpha15 Stable Cell Line-Chem-1

Human ADRB1/Galpha15 Stable Cell Line-Chem-1

The endogenous catecholamines epinephrine and norepinephrine have profound effects on smooth muscle activity, cardiac function, carbohydrate and fat metabolism, hormone secretion, neurotransmitter release, and central Human ADRBK2/Galpha15 Stable Cell Line-Chem-1

Human ADRBK2/Galpha15 Stable Cell Line-Chem-1

The endogenous catecholamines epinephrine and norepinephrine have profound effects on smooth muscle activity, cardiac function, carbohydrate and fat metabolism, hormone secretion, neurotransmitter release, and central Human ADRB3/Galpha15 Stable Cell Line-Chem-10

Human ADRB3/Galpha15 Stable Cell Line-Chem-10

The endogenous catecholamines epinephrine and norepinephrine have profound effects on smooth muscle activity, cardiac function, carbohydrate and fat metabolism, hormone secretion, neurotransmitter release, and central Human OXGR1/Galpha15 Stable Cell Line-Chem-1

Human OXGR1/Galpha15 Stable Cell Line-Chem-1

GPR99 (also known as GPR80) was originally identified as an orphan with a sequence most closely related to P2Y receptors. Studies to deorphanize GPR99 revealed that alpha-ketoglutarate activates GPR99 through Gq to in Human C3AR1/Galpha15 Stable Cell Line-Chem-1

Human C3AR1/Galpha15 Stable Cell Line-Chem-1

C3a, along with C4a and C5a, is a 77 amino acid anaphylotoxin generated by proteolytic cleavage during activation of the complement pathway. The anaphylotoxins strongly promote inflammation by recruiting leukocytes, p Human C5AR1/Galpha15 Stable Cell Line-Chem-1

Human C5AR1/Galpha15 Stable Cell Line-Chem-1

C5a is a proinflammatory peptide generated through activation of the complement system, and is more potent than the other anaphylatoxins, C4a and C3a, in activating peripheral blood leukocytes. It can actively partici Human GCGR/Galpha15 Stable Cell Line-Chem-1

Human GCGR/Galpha15 Stable Cell Line-Chem-1

Glucagon is a 29-amino acid peptide that stimulates glycogenolysis and gluconeogenesis in the liver to increase blood glucose. The receptor for glucagon is a class 2 (or class B) GPCR that signals through Gs to stimul Human SCTR/Galpha15 Stable Cell Line-Chem-1

Human SCTR/Galpha15 Stable Cell Line-Chem-1

Secretin, a member of the secretin-glucagon peptide hormone family, is a 27 amino acid peptide that was originally isolated from the duodenum. In the duodenum, secretin is released to stimulate the release of digestiv Human GRM1/Galpha15 Stable Cell Line-Chem-3

Human GRM1/Galpha15 Stable Cell Line-Chem-3

Glutamate is a main excitatory neurotransmitter in the central nervous system, and it plays a role in learning, memory and neurotoxicity. The biological actions of glutamate are mediated by ionotropic and metabotropic Human AGTR1/Galpha15 Stable Cell Line-Chem-1

Human AGTR1/Galpha15 Stable Cell Line-Chem-1

Angiotensin II (Ang II), an octapeptide produced by cleavage of angiotensinogen by angiotensin-converting enzyme, plays a fundamental role in cardiovascular homeostasis. Two GPCRs, AT1 and AT2, mediate the effects of Human APLNR/Galpha15 Stable Cell Line-Chem-5

Human APLNR/Galpha15 Stable Cell Line-Chem-5

Apelin peptides have been discovered to be a family of peptides of different sizes that is derived from the N-terminus of a 77 amino acid precursor peptide (preproapelin). Apelin receptor (APJ) is a G protein-coupled Human GPBAR1/Clytin Stable Cell Line-HEK293

Human GPBAR1/Clytin Stable Cell Line-HEK293

The bile acid lithocolic acid acts as an agonist on the GPBA GPCR, also known as GPR131 or TGR5, to increase intracellular cAMP in cells that express the receptor. Bile acids and other GPBA ligands increase glucagon-l
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